Article
A transient mutational burst occurs during yeast colony development.
Molecular systems biology - 1 Sept 2025
Agier Nicolas, Vittorelli Nina, Ollivier Louis, Chaux Frédéric, Gillet-Markowska Alexandre, O'Donnell Samuel, Pouyet Fanny, Fischer Gilles, Delmas Stéphane
Abstract excerpt
Characterizing the contribution of mutators to mutation accumulation is essential for understanding cellular adaptation and diseases like cancer. By measuring single and double mutation rates, including point mutations, segmental duplications, and reciprocal translocations, we found that wild-type yeast colonies exhibit double mutation rates up to 17 times higher than expected from experimentally determined...
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