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Article

Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected.

Genetics - 1 Dec 2004

Joseph Sarah B, Hall David W

Abstract excerpt

We performed a 1012-generation mutation-accumulation (MA) experiment in the yeast, Saccharomyces cerevisiae. The MA lines exhibited a significant reduction in mean fitness and a significant increase in variance in fitness. We found that 5.75% of the fitness-altering mutations accumulated were beneficial. This finding contradicts the widely held belief that nearly all fitness-altering mutations are deleterious....

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Identifiers

PMID: 15611159
DOI: 10.1534/genetics.104.033761
PMCID: PMC1448740

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Source receipt: pubmed, retrieved 7 Sept 2026.

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