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Article

The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2018

Sharp Nathaniel P, Sandell Linnea, James Christopher G, Otto Sarah P

Abstract excerpt

By altering the dynamics of DNA replication and repair, alternative ploidy states may experience different rates and types of new mutations, leading to divergent evolutionary outcomes. We report a direct comparison of the genome-wide spectrum of spontaneous mutations arising in haploids and diploids following a mutation-accumulation experiment in the budding yeast Saccharomyces cerevisiae Characterizing the...

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Identifiers

PMID: 29760081
DOI: 10.1073/pnas.1801040115
PMCID: PMC5984525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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