Complementation of HLA-DQA and -DQB genes confers susceptibility and protection to insulin-dependent diabetes mellitus.

doi:10.1016/0198-8859(92)90046-p

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Article

Complementation of HLA-DQA and -DQB genes confers susceptibility and protection to insulin-dependent diabetes mellitus.

Human immunology - 1 Jan 1992

Heimberg H, Nagy Z P, Somers G, De Leeuw I, Schuit F C

Abstract excerpt

Lack of an aspartic acid 57 in the HLA-DQ beta chain was introduced as a genetic marker of insulin-dependent diabetes mellitus (IDDM). Because 25% of the control population carries the same marker, we analyzed the DQ locus for the presence of more specific disease susceptibility markers, taking into account a possible role for the polymorphic DQA gene. We thereby identified the DQA3-DQB3.2/DQA4.1-DQB2...

Topics

Adolescent
Adult
Age Factors
Aged
Alleles
Arginine
Asparagine
Base Sequence
Child
Child, Preschool
DNA Probes
Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Disease Susceptibility

Female

Genetic Complementation Test

Genotype

HLA-DQ Antigens

HLA-DQ alpha-Chains

Source

Open in PubMed

Identifiers

PMID: 1548146
DOI: 10.1016/0198-8859(92)90046-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1548146-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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