Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complementation of HLA-DQA and -DQB genes confers susceptibility and protection to insulin-dependent diabetes mellitus.

Human immunology - 1 Jan 1992

Heimberg H, Nagy Z P, Somers G, De Leeuw I, Schuit F C

Abstract excerpt

Lack of an aspartic acid 57 in the HLA-DQ beta chain was introduced as a genetic marker of insulin-dependent diabetes mellitus (IDDM). Because 25% of the control population carries the same marker, we analyzed the DQ locus for the presence of more specific disease susceptibility markers, taking into account a possible role for the polymorphic DQA gene. We thereby identified the DQA3-DQB3.2/DQA4.1-DQB2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Sequence

Share to Child, Preschool

Share to Genetic Complementation Test

Share to Genotype

Source

Identifiers

PMID: 1548146
DOI: 10.1016/0198-8859(92)90046-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complementation of HLA-DQA and -DQB genes confers susceptibility and protection to insulin-dependent diabetes mellitus.PMID 1548146Read ↗

Insulin-dependent diabetes mellitus in non-DR3/non-DR4 subjects.Semantic proximity Read ↗

The role of genetic predisposition to type I (insulin-dependent) diabetes mellitus.Semantic proximity Read ↗

DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.Semantic proximity Read ↗

Analysis of HLA-DQA1 and -DQB1 genes in Mexican Americans with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Prevalence of HLA-DQ beta chain non-Asp alleles in type I (insulin-dependent) diabetics with young and older ages of onset.Semantic proximity Read ↗

The complex interplay of the DQB1 and DQA1 loci in the generation of the susceptible and protective phenotype for insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Changes in frequency of IDDM-associated HLA DQB, CTLA4 and INS alleles.Semantic proximity Read ↗

Increased and decreased relative risk for non-insulin-dependent diabetes mellitus conferred by HLA class II and by CD4 alleles.Semantic proximity Read ↗

[Respective weight of genotypes DQA1 and DQB1 associated with insulin-dependent diabetes in French children].Semantic proximity Read ↗

Comparison between HLA-DRB and DQ DNA sequences and classic serological markers as type 1 (insulin-dependent) diabetes mellitus predictive risk markers in the Spanish population.Semantic proximity Read ↗

HLA-DQB 1 codon 57 and genetic susceptibility to type 1 (insulin-dependent) diabetes mellitus in French children.Semantic proximity Read ↗

HLA-DQA and DQB alleles contribute to susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.