Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-DQB 1 codon 57 and genetic susceptibility to type 1 (insulin-dependent) diabetes mellitus in French children.

Diabetologia - 1 Mar 1990

Vallet-Colom I, Lévy-Marchal C, Zarrouk D, Tichet J, Krishnamoorthy R, Czernichow P, Elion J

Abstract excerpt

Variations in the incidence rate of Type 1 (insulin-dependent) diabetes mellitus might relate to ethnic-specific genetic backgrounds. HLA-DQB 1 alleles were typed in 75 French diabetic children and 85 matched control children. Enzymatically-amplified DQB 1 exon 2 was hybridized with oligoprobes specific for the six most common alleles. Alleles coding for an Asp residue at position 57 in the DQ beta chain are...

Topics

Alanine
Alleles
Aspartic Acid
Child
Codon
Diabetes Mellitus, Type 1
France
Gene Frequency
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ beta-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Humans

RNA, Messenger

Source

Identifiers

PMID: 2328849
DOI: 10.1007/BF00404046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2328849-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DQB 1 codon 57 and genetic susceptibility to type 1 (insulin-dependent) diabetes mellitus in French children.PMID 2328849Read ↗

Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain.Semantic proximity Read ↗

Susceptibility to type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ alpha Arg 52 and HLA-DQ beta non-Asp 57 alleles.Semantic proximity Read ↗

Analysis of HLA-DQA1 and -DQB1 genes in Mexican Americans with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

HLA-DQA and DQB alleles contribute to susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.Semantic proximity Read ↗

HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland.Semantic proximity Read ↗

Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Genetic susceptibility to type I diabetes: a review.Semantic proximity Read ↗

HLA-DQA1 and DQB1 alleles in French and Algerian type 1 diabetic subjects.Semantic proximity Read ↗

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.Semantic proximity Read ↗

[Respective weight of genotypes DQA1 and DQB1 associated with insulin-dependent diabetes in French children].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.