Article
Insulin-dependent diabetes mellitus in non-DR3/non-DR4 subjects.
Human immunology - 1 Oct 1997
Dubois-Laforgue D, Timsit J, Djilali-Saiah I, Boitard C, Caillat-Zucman S
Abstract excerpt
Five to 20% insulin-dependent diabetes mellitus (IDDM) patients do not bear the classical HLA class II DR3 or DR4 susceptibility haplotypes. We have studied the clinical characteristics, anti-islet cell antibodies (Ab) and HLA class II genotypes in 72 non-DR3/non-DR4 Caucasian patients, mainly adults, presenting with clinically typical IDDM. The DRB1*08-DQB1*0402-DQA1*0401 haplotype frequency was increased in the...
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