Article
Comparison between HLA-DRB and DQ DNA sequences and classic serological markers as type 1 (insulin-dependent) diabetes mellitus predictive risk markers in the Spanish population.
Diabetologia - 1 May 1992
Vicario J L, Martinez-Laso J, Corell A, Martin-Villa J M, Morales P, Lledo G, Segurado O G, de Juan D, Arnaiz-Villena A
Abstract excerpt
The question of HLA susceptibility to Type 1 (insulin-dependent) diabetes mellitus remains unresolved. In the present study, 127 diabetic patients and 177 unrelated control subjects have been analysed for their class I and class II serological antigens, class II (DR, DQ) DNA restriction fragment length polymorphisms and DQA1 and B1 exon-2 nucleotide sequences and their corresponding amino acid residues. By using...
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