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DRB10403 protects against IDDM in Caucasians with the high-risk heterozygous DQA10301-DQB10302/DQA10501-DQB1*0201 genotype. Belgian Diabetes Registry.

Diabetes - 1 May 1995

Van der Auwera B, Van Waeyenberge C, Schuit F, Heimberg H, Vandewalle C, Gorus F, Flament J

Abstract excerpt

The human leukocyte antigen (HLA) class II genotype DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 has been identified as a marker strongly predisposing to insulin-dependent diabetes mellitus (IDDM) in Caucasian populations. Its frequency in control populations (1-3%) is still, however, 1 order of magnitude higher than the prevalence of IDDM, suggesting that its penetrance can be modified by protective factors. In this...

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PMID: 7729610
DOI: 10.2337/diab.44.5.527

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