DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.

doi:10.2337/diab.44.5.527

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Article

DRB10403 protects against IDDM in Caucasians with the high-risk heterozygous DQA10301-DQB10302/DQA10501-DQB1*0201 genotype. Belgian Diabetes Registry.

Diabetes - 1 May 1995

Van der Auwera B, Van Waeyenberge C, Schuit F, Heimberg H, Vandewalle C, Gorus F, Flament J

Abstract excerpt

The human leukocyte antigen (HLA) class II genotype DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 has been identified as a marker strongly predisposing to insulin-dependent diabetes mellitus (IDDM) in Caucasian populations. Its frequency in control populations (1-3%) is still, however, 1 order of magni...

Topics

Alleles
Base Sequence
DNA Probes
Diabetes Mellitus, Type 1
Female
Gene Frequency
Genetic Markers
Genotype
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DR Antigens
HLA-DRB1 Chains
Haplotypes
Heterozygote
Humans
Male
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7729610
DOI: 10.2337/diab.44.5.527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7729610-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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