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Article

The role of genetic predisposition to type I (insulin-dependent) diabetes mellitus.

Annals of medicine - 1 Oct 1991

Deschamps I, Beressi J P, Khalil I, Robert J J, Hors J

Abstract excerpt

The aetiology of insulin-dependent diabetes (IDDM) involves genetic predisposition, a major component of which has been mapped in the HLA complex, near to or identical with genes encoding class II molecules. In Caucasian populations IDDM is strongly associated with the serologically defined HLA-DR3 and DR4 antigens, which are widely recognised as markers of susceptibility. The particularly high risk of DR3/DR4...

Topics

Diabetes Mellitus, Type 1
Genetic Markers
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DR3 Antigen
HLA-DR4 Antigen
Heterozygote
Humans
Incidence
Polymorphism, Genetic
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1930940
DOI: 10.3109/07853899109148086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1930940-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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