Article
The complex interplay of the DQB1 and DQA1 loci in the generation of the susceptible and protective phenotype for insulin-dependent diabetes mellitus.
Molecular immunology - 1 Apr 1994
Tosi G, Brunelli S, Mantero G, Magalini A R, Soffiati M, Pinelli L, Tridente G, Accolla R S
Abstract excerpt
IDDM patients of North East Italian region were molecularly typed for their HLA-DQB1 and DQA1 loci by using allele specific oligonucleotide probes and PCR amplified genomic DNA. IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid residue in position 57 of DQ beta chain...
Topics
- Alleles
- Base Sequence
- Diabetes Mellitus, Type 1
- Female
- Genes, MHC Class II
- Genetic Linkage
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- Haplotypes
- Histocompatibility Testing
- Humans
- Italy
- Male
- Molecular Sequence Data
- Oligonucleotide Probes