Article
A new effector pathway links ATM kinase with the DNA damage response.
Nature cell biology - 1 Oct 2004
Demonacos Constantinos, Krstic-Demonacos Marija, Smith Linda, Xu Danmei, O'Connor Darran P, Jansson Martin, La Thangue Nicholas B
Abstract excerpt
The related kinases ATM (ataxia-telangiectasia mutated) and ATR (ataxia-telangiectasia and Rad3-related) phosphorylate a limited number of downstream protein targets in response to DNA damage. Here we report a new pathway in which ATM kinase signals the DNA damage response by targeting the transcriptional cofactor Strap. ATM phosphorylates Strap at a serine residue, stabilizing nuclear Strap and facilitating...
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