Article
ATM: from gene to function.
Human molecular genetics - 1 Jan 1998
Rotman G, Shiloh Y
Abstract excerpt
The identification of ATM , the gene responsible for the pleiotropic recessive disease ataxia telangiectasia, has initiated extensive research to determine the functions of its multifaceted protein product. The ATM protein belongs to a family of protein kinases that share similarities at their C-...
Topics
- Animals
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Catalytic Domain
- Cell Cycle Proteins
- DNA-Binding Proteins
- Disease Models, Animal
- Female
- Genes, Tumor Suppressor
- Genotype
- Growth Disorders
- Humans
- Male
- Meiosis
- Mice
- Mice, Knockout
- Mutation
- Neoplasms, Experimental