Article
Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response.
Acta medica (Hradec Kralove) - 1 Jan 2010
Tichý Ales, Vávrová Jirina, Pejchal Jaroslav, Rezácová Martina
Abstract excerpt
Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, cell-cycle progress, and apoptosis. Here we describe its main signalling targets and discuss its importance in DNA repair as well as novel findings linked to this key...
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