Article
Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response.
Acta medica (Hradec Kralove) - 1 Jan 2010
Tichý Ales, Vávrová Jirina, Pejchal Jaroslav, Rezácová Martina
Abstract excerpt
Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, cell-cycle progress, and apoptosis. Here we describe its main signalling targets and discuss its importance in DNA repair as well as novel findings linked to this key...
Topics
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle
- Cell Cycle Proteins
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Humans
- Mutation
- Protein Serine-Threonine Kinases
- Tumor Suppressor Proteins