Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.

Science (New York, N.Y.) - 25 Aug 2006

Dornan David, Shimizu Harumi, Mah Angie, Dudhela Tanay, Eby Michael, O'rourke Karen, Seshagiri Somasekar, Dixit Vishva M

Abstract excerpt

The ataxia telangiectasia mutated (ATM) protein kinase is a critical component of a DNA-damage response network configured to maintain genomic integrity. The abundance of an essential downstream effecter of this pathway, the tumor suppressor protein p53, is tightly regulated by controlled degradation through COP1 and other E3 ubiquitin ligases, such as MDM2 and Pirh2; however, the signal transduction pathway that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Etoposide

Share to Phosphoserine

Share to Proteasome Endopeptidase Complex

Share to Radiation, Ionizing

Share to RNA, Small Interfering

Share to Ubiquitin

Source

Identifiers

PMID: 16931761
DOI: 10.1126/science.1127335

Genes

COP1
ATM
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.PMID 16931761Read ↗

ATM kinase: Much more than a DNA damage responsive protein.Semantic proximity Read ↗

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.Semantic proximity Read ↗

TRIM24 Is a p53-Induced E3-Ubiquitin Ligase That Undergoes ATM-Mediated Phosphorylation and Autodegradation during DNA DamageSemantic proximity Read ↗

Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response.Semantic proximity Read ↗

ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.Semantic proximity Read ↗

Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large OrchestraSemantic proximity Read ↗

Profiling of UV-induced ATM/ATR signaling pathwaysSemantic proximity Read ↗

A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.Semantic proximity Read ↗

ATM&A Key Determinant of Multiple Cellular Responses to IrradiationSemantic proximity Read ↗

Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stressSemantic proximity Read ↗

ATR signaling at a glanceSemantic proximity Read ↗

Role of the COP1 protein in cancer development and therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.