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Article

ATM: the product of the gene mutated in ataxia-telangiectasia.

The international journal of biochemistry & cell biology - 1 Jul 1999

Lavin M F

Abstract excerpt

Ataxia-telangiectasia mutated (ATM) is the product of the gene mutated in the human genetic disorder ataxia-telangeictasia (A-T). It is a 370 kDa protein that is a member of the phosphatidyl inositol 3-kinases superfamily. A-T cells and those derived from Atm-/- mice are characterized by hypersensitivity to ionizing radiation and defective cell cycle checkpoints. Defects are observed at all cell cycle checkpoints...

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Source

Identifiers

PMID: 10467728
DOI: 10.1016/s1357-2725(99)00028-x

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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