ATM: the product of the gene mutated in ataxia-telangiectasia.

doi:10.1016/s1357-2725(99)00028-x

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Article

ATM: the product of the gene mutated in ataxia-telangiectasia.

The international journal of biochemistry & cell biology - 1 Jul 1999

Lavin M F

Abstract excerpt

Ataxia-telangiectasia mutated (ATM) is the product of the gene mutated in the human genetic disorder ataxia-telangeictasia (A-T). It is a 370 kDa protein that is a member of the phosphatidyl inositol 3-kinases superfamily. A-T cells and those derived from Atm-/- mice are characterized by hypersensitivity to ionizing radiation and defective cell cycle checkpoints. Defects are observed at all cell cycle checkpoints...

Topics

Animals
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Proteins
Cell Cycle
Cell Cycle Proteins
DNA Damage
DNA-Binding Proteins
Humans
Mice
Mice, Knockout
Mutation
Nerve Degeneration
Protein Serine-Threonine Kinases
Proteins
Radiation Tolerance
Signal Transduction
Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 10467728
DOI: 10.1016/s1357-2725(99)00028-x

Genes

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