Article
Signalling DNA damage by regulating p53 co-factor activity.
Cell cycle (Georgetown, Tex.) - 1 Jan 2005
Smith Linda, La Thangue Nicholas B
Abstract excerpt
In response to DNA damage the related phosphatidylinositol-3-OH-kinase-like-kinases ATM and ATR phosphorylate downstream protein targets which facilitate the DNA damage response. A new pathway in which ATM phosphorylates the transcriptional co-factor Strap has been elucidated. Phosphorylation causes the stabilization of nuclear Strap and favours the formation of a stress-responsive co-activator complex. Strap...
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