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Article

ATR and ATRIP: Partners in Checkpoint Signaling

23 Nov 2001

Abstract excerpt

The checkpoint kinases ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3 related) transduce genomic stress signals to halt cell cycle progression and promote DNA repair. We report the identification of an ATR-interacting protein (ATRIP) that is phosphorylated by ATR, regulates ATR expression, and is an essential component of the DNA damage checkpoint pathway. ATR and ATRIP both localize to intranuclear...

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Identifiers

PMID: 11721054
DOI: 10.1126/science.1065521

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Related research

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ATR and ATRIP: Partners in Checkpoint SignalingPMID 11721054Read ↗

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The DNA damage response to ATR inhibitionSemantic proximity Read ↗

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ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway.Semantic proximity Read ↗

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stressSemantic proximity Read ↗

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.Semantic proximity Read ↗

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Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis.Semantic proximity Read ↗

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