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Article

Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit.

Science (New York, N.Y.) - 22 Jun 2001

Brown C E, Howe L, Sousa K, Alley S C, Carrozza M J, Tan S, Workman J L

Abstract excerpt

Promoter-specific recruitment of histone acetyltransferase activity is often critical for transcriptional activation. We present a detailed study of the interaction between the histone acetyltransferase complexes SAGA and NuA4, and transcription activators. We demonstrate by affinity chromatography and photo-cross-linking label transfer that acidic activators directly interact with Tra1p, a shared subunit of SAGA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11423663
DOI: 10.1126/science.1060214

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit.PMID 11423663Read ↗

Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.Semantic proximity Read ↗

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A new effector pathway links ATM kinase with the DNA damage response.Semantic proximity Read ↗

The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.Semantic proximity Read ↗

Multivalent Binding of p53 to the STAGA Complex Mediates Coactivator Recruitment after UV DamageSemantic proximity Read ↗

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Differential requirement of SAGA components for recruitment of TATA-box-binding protein to promoters in vivo.Semantic proximity Read ↗

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