ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.

doi:10.1080/095530099139359

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Article

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.

International journal of radiation biology - 1 Oct 1999

Lavin M F, Khanna K K

Abstract excerpt

PURPOSE: To provide an update on the product of the ATM gene mutated in the human genetic disorder ataxia-telangiectasia (A-T). SUMMARY: The product of the ATM gene mutated in the human genetic disorder A-T is a 350 kDa protein that plays a central role in the regulation of a number of cellular processes. It is a member of the phosphatidylinositol 3-kinase superfamily, but is more likely a protein kinase similar...

Topics

Animals
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Proteins
Cell Cycle
Cell Cycle Proteins
DNA Damage
DNA-Binding Proteins
Female
Humans
Male
Meiosis
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Mutation

Protein Serine-Threonine Kinases

Proteins

Radiation Tolerance

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 10549596
DOI: 10.1080/095530099139359

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