Article
The many substrates and functions of ATM.
Nature reviews. Molecular cell biology - 1 Dec 2000
Kastan M B, Lim D S
Abstract excerpt
As its name suggests, the ATM--'ataxia-telangiectasia, mutated'--gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge.
Topics
- Amino Acid Sequence
- Animals
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle
- Cell Cycle Proteins
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Humans
- Models, Biological
- Molecular Sequence Data
- Phenotype
- Protein Serine-Threonine Kinases
- Sequence Homology, Amino Acid
- Tumor Suppressor Proteins