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Article

Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism.

The Journal of biological chemistry - 12 Nov 2004

Lam Amy K M, Ko Ben C B, Tam Sidney, Morris Ryan, Yang James Y, Chung Sookja K, Chung Stephen S M

Abstract excerpt

OREBP (osmotic response element-binding protein), also called TonEBP or NFAT5, is thought to induce the expression of genes that increase the accumulation of organic osmolytes to protect cells against a hypertonic environment. To investigate the consequences of lacking OREBP activity, transgenic (Tg) mice that overexpress OREBPdn (dominant negative form of OREBP) specifically in the epithelial cells of the renal...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15347663
DOI: 10.1074/jbc.M407224200

Genes

AQP2
NFAT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism.PMID 15347663Read ↗

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