Article
Activating transcription factor 6α is required for the vasopressin neuron system to maintain water balance under dehydration in male mice.
Endocrinology - 1 Dec 2014
Azuma Yoshinori, Hagiwara Daisuke, Lu Wenjun, Morishita Yoshiaki, Suga Hidetaka, Goto Motomitsu, Banno Ryoichi, Sugimura Yoshihisa, Oyadomari Seiichi, Mori Kazutoshi, Shiota Akira, Asai Naoya, Takahashi Masahide, Oiso Yutaka, Arima Hiroshi
Abstract excerpt
Activating transcription factor 6α (ATF6α) is a sensor of endoplasmic reticulum (ER) stress and increases the expression of ER chaperones and molecules related to the ER-associated degradation of unfolded/misfolded proteins. In this study, we used ATF6α knockout (ATF6α(-/-)) mice to clarify the role of ATF6α in the arginine vasopressin (AVP) neuron system. Although urine volumes were not different between...
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