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Article

Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2.

Molecular and cellular biology - 1 Aug 2005

Uchida Shinichi, Sohara Eisei, Rai Tatemitsu, Ikawa Masahito, Okabe Masaru, Sasaki Sei

Abstract excerpt

Urea transporter UT-A2, the major urea transporter of the thin descending limb of the loop of Henle in short loop nephrons, has been implicated in urea recycling in the medulla, thereby producing concentrated urine. To investigate the physiological role of UT-A2 in vivo, we generated UT-A2-selective knockout mice by deleting the UT-A2 promoter. Western analysis, immunohistochemistry, and quantitative reverse...

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Identifiers

PMID: 16055743
DOI: 10.1128/MCB.25.16.7357-7363.2005
PMCID: PMC1190230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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