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Article

The evolving role of TonEBP as an immunometabolic stress protein.

Nature reviews. Nephrology - 1 Jun 2020

Choi Soo Youn, Lee-Kwon Whaseon, Kwon Hyug Moo

Abstract excerpt

Tonicity-responsive enhancer-binding protein (TonEBP), which is also known as nuclear factor of activated T cells 5 (NFAT5), was discovered 20 years ago as a transcriptional regulator of the cellular response to hypertonic (hyperosmotic salinity) stress in the renal medulla. Numerous studies since then have revealed that TonEBP is a pleiotropic stress protein that is involved in a range of immunometabolic...

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PMID: 32157251
DOI: 10.1038/s41581-020-0261-1

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The evolving role of TonEBP as an immunometabolic stress protein.PMID 32157251Read ↗

NFAT5 in cellular adaptation to hypertonic stress – regulations and functional significanceSemantic proximity Read ↗

The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP.Semantic proximity Read ↗

Tonicity-Responsive Enhancer-Binding Protein Mediates Hyperglycemia-Induced Inflammation and Vascular and Renal Injury.Semantic proximity Read ↗

High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.Semantic proximity Read ↗

NFAT5 Confers Differential Expression in Innate Immune Cells vs. Renal Epithelial Cells in the Face of Osmotic StressSemantic proximity Read ↗

RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus CellsSemantic proximity Read ↗

Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress.Semantic proximity Read ↗

PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammationSemantic proximity Read ↗

HES1 contributes to high salt stress response as an enhancer of NFAT5-DNA bindingSemantic proximity Read ↗

Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks.Semantic proximity Read ↗

Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights.Semantic proximity Read ↗

TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beigingSemantic proximity Read ↗

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