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Article

Increased Expression of Orexin-A in Patients Affected by Polycystic Kidney Disease.

International journal of molecular sciences - 5 Jun 2024

Nigro Ersilia, D'Arco Daniela, Moscatelli Fiorenzo, Pisani Antonio, Amicone Maria, Riccio Eleonora, Capuano Ivana, Argentino Francesca, Monda Marcellino, Messina Giovanni, Daniele Aurora, Polito Rita

Abstract excerpt

Orexin-A is a neuropeptide product of the lateral hypothalamus that acts on two receptors, OX1R and OX2R. The orexinergic system is involved in feeding, sleep, and pressure regulation. Recently, orexin-A levels have been found to be negatively correlated with renal function. Here, we analyzed orexin-A levels as well as the incidence of SNPs in the hypocretin neuropeptide precursor (HCRT) and its receptors, HCRTR1...

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Identifiers

PMID: 38892431
DOI: 10.3390/ijms25116243
PMCID: PMC11172798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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