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Article

The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP.

The Journal of biological chemistry - 8 Oct 2010

Lanaspa Miguel A, Andres-Hernando Ana, Li Nanxing, Rivard Christopher J, Cicerchi Christina, Roncal-Jimenez Carlos, Schrier Robert W, Berl Tomas

Abstract excerpt

Expression of aquaporin-1 (AQP1) and -2 (AQP2) channels in the kidney are critical for the maintenance of water homeostasis and the operation of the urinary concentrating mechanism. Hypertonic stress induced in inner medullary (IMCD3) cells by addition of NaCl to the medium substantially up-regulated the mRNA and protein expression of AQP1, suggesting that its activation occurs at a transcriptional and a...

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Source

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Identifiers

PMID: 20639513
DOI: 10.1074/jbc.M109.093690
PMCID: PMC2951241

Genes

AQP1
AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP.PMID 20639513Read ↗

The evolving role of TonEBP as an immunometabolic stress protein.Semantic proximity Read ↗

High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.Semantic proximity Read ↗

Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress.Semantic proximity Read ↗

Dynamic regulation and dysregulation of the water channel aquaporin-2: a common cause of and promising therapeutic target for water balance disorders.Semantic proximity Read ↗

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents.Semantic proximity Read ↗

NFAT5 Confers Differential Expression in Innate Immune Cells vs. Renal Epithelial Cells in the Face of Osmotic StressSemantic proximity Read ↗

NFAT5 in cellular adaptation to hypertonic stress – regulations and functional significanceSemantic proximity Read ↗

Hypotonicity-induced reduction of aquaporin-2 transcription in mpkCCD cells is independent of the tonicity responsive element, vasopressin, and cAMP.Semantic proximity Read ↗

Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks.Semantic proximity Read ↗

Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism.Semantic proximity Read ↗

Cis- and trans-acting factors regulating transcription of the BGT1 gene in response to hypertonicity.Semantic proximity Read ↗

PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammationSemantic proximity Read ↗

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