Article
Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents.
The Journal of clinical investigation - 1 Jun 2009
Chen Songcang, Grigsby Christopher L, Law Christopher S, Ni Xiping, Nekrep Nada, Olsen Keith, Humphreys Michael H, Gardner David G
Abstract excerpt
In various mammalian species, including humans, water restriction leads to an acute increase in urinary sodium excretion. This process, known as dehydration natriuresis, helps prevent further accentuation of hypernatremia and the accompanying rise in extracellular tonicity. Serum- and glucocorticoid-inducible kinase (Sgk1), which is expressed in the renal medulla, is regulated by extracellular tonicity. However,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.