Article
Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks.
The Journal of biological chemistry - 20 May 2005
Wang Yu, Ko Ben C B, Yang James Y, Lam Terrence T L, Jiang Zhirong, Zhang Jinsong, Chung Sookja K, Chung Stephen S M
Abstract excerpt
Osmotic-response element-binding protein (OREBP), also known as TonEBP or NFAT5, is thought to be responsible for the induction of osmolyte-accumulating genes when cells are under hypertonic stress. Recent studies suggest that OREBP also plays a role in water reabsorption in the kidney, T-cell proliferation, and embryonic development. We developed transgenic mice that express the dominant-negative OREBP (OREBPdn)...
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