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Article

Hypoxia affects mesoderm and enhances hemangioblast specification during early development.

Development (Cambridge, England) - 1 Sept 2004

Ramírez-Bergeron Diana L, Runge Anja, Dahl Karen D Cowden, Fehling Hans Joerg, Keller Gordon, Simon M Celeste

Abstract excerpt

Hypoxia Inducible Factor (HIF), consisting of HIF1alpha and ARNT (HIF1beta) subunits, activates multiple genes in response to oxygen (O(2)) deprivation. Arnt(-/-) mice exhibit substantial defects in blood cell and vessel development. We demonstrate that hypoxia accelerates the expression of Brachyury (a mesoderm-specific transcription factor), BMP4 (a mesoderm-promoting growth factor) and FLK1 (a marker of...

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Share to Aryl Hydrocarbon Receptor Nuclear Translocator
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Source

Identifiers

PMID: 15342485
DOI: 10.1242/dev.01310

Genes

ARNT
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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