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Article

Smad1 expands the hemangioblast population within a limited developmental window

21 Sept 2006

Abstract excerpt

Bone morphogenetic protein (BMP) signaling is an important regulator of hematovascular development. However, the progenitor population that responds to BMP signaling is undefined, and the relative role of downstream mediators including Smad1 is unclear. We find that Smad1 shows a distinctive expression profile as embryonic stem (ES) cells undergo differentiation in the embryoid body (EB) system, with peak levels...

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PMID: 16990609
DOI: 10.1182/blood-2006-02-004564

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