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Article

Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription.

Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2015

Koh Fong Ming, Lizama Carlos O, Wong Priscilla, Hawkins John S, Zovein Ann C, Ramalho-Santos Miguel

Abstract excerpt

Lineage specification during development involves reprogramming of transcriptional states, but little is known about how this is regulated in vivo. The chromatin remodeler chomodomain helicase DNA-binding protein 1 (Chd1) promotes an elevated transcriptional output in mouse embryonic stem cells. Here we report that endothelial-specific deletion of Chd1 leads to loss of definitive hematopoietic progenitors,...

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Identifiers

PMID: 25831528
DOI: 10.1073/pnas.1424850112
PMCID: PMC4394284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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