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Article

Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner.

Stem cells (Dayton, Ohio) - 1 Nov 2008

Purpura Kelly A, George Sophia H L, Dang Stephen M, Choi Kyunghee, Nagy Andras, Zandstra Peter W

Abstract excerpt

Vascular endothelial growth factor (VEGF) and the vascular endothelial growth factor receptors (VEGFRs) regulate the development of hemogenic mesoderm. Oxygen concentration-mediated activation of hypoxia-inducible factor targets such as VEGF may serve as the molecular link between the microenvironment and mesoderm-derived blood and endothelial cell specification. We used controlled-oxygen microenvironments to...

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Source

Identifiers

PMID: 18772315
DOI: 10.1634/stemcells.2008-0237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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