Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APELIN promotes hematopoiesis from human embryonic stem cells

20 May 2012

Abstract excerpt

Transcriptional profiling of differentiating human embryonic stem cells (hESCs) revealed that MIXL1-positive mesodermal precursors were enriched for transcripts encoding the G-protein-coupled APELIN receptor (APLNR). APLNR-positive cells, identified by binding of the fluoresceinated peptide ligand, APELIN (APLN), or an anti-APLNR mAb, were found in both posterior mesoderm and anterior mesendoderm populations and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apelin-related biomedical research
Share to Macrophage Migration Inhibitory Factor
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22611158
DOI: 10.1182/blood-2011-12-396093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APELIN promotes hematopoiesis from human embryonic stem cellsPMID 22611158Read ↗

Apelin signaling drives vascular endothelial cells toward a pro-angiogenic stateSemantic proximity Read ↗

ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cellsSemantic proximity Read ↗

Pleiotrophin Enhances Clonal Growth and Long-Term Expansion of Human Embryonic Stem CellsSemantic proximity Read ↗

Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow nichesSemantic proximity Read ↗

Modulation of WNT, Activin/Nodal and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation During Human iPSC DifferentiationSemantic proximity Read ↗

Leukemia-derived apelin selects endothelial niche clones to promote tumorigenesisSemantic proximity Read ↗

Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.Semantic proximity Read ↗

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cellsSemantic proximity Read ↗

Arterial cells support the development of human hematopoietic progenitors in vitro via secretion of IGFBP2Semantic proximity Read ↗

Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafishSemantic proximity Read ↗

Activin and BMP4 Synergistically Promote Formation of Definitive Endoderm in Human Embryonic Stem CellsSemantic proximity Read ↗

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.