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Article

Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.

Molecular and cellular biology - 1 Dec 2005

Cowden Dahl Karen D, Fryer Benjamin H, Mack Fiona A, Compernolle Veerle, Maltepe Emin, Adelman David M, Carmeliet Peter, Simon M Celeste

Abstract excerpt

Placental development initially occurs in a low-oxygen (O2) or hypoxic environment. In this report we show that two hypoxia-inducible factors (HIFs), HIF1alpha and HIF2alpha, are essential for determining murine placental cell fates. HIF is a heterodimer composed of HIFalpha and HIFbeta (ARNT) subunits. Placentas from Arnt-/- and Hif1alpha-/- Hif2alpha-/- embryos exhibit defective placental vascularization and...

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Identifiers

PMID: 16287860
DOI: 10.1128/MCB.25.23.10479-10491.2005
PMCID: PMC1291235

Genes

ARNT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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