Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish

26 Nov 2013

Abstract excerpt

The hemangioblast is a multipotential progenitor, which is derived from the mesoderm and can further differentiate into hematopoietic and endothelial lineages. The molecular mechanism governing the specification of hemangioblasts is fundamental to regenerative medicine based on embryonic stem cells for the treatment of various hematologic and vascular diseases. Here we show that aggf1 acts at the top of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Zebrafish Biomedical Research Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24277077
DOI: 10.1182/blood-2013-07-514612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafishPMID 24277077Read ↗

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1Semantic proximity Read ↗

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.Semantic proximity Read ↗

Functional characterization of Klippel–Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesisSemantic proximity Read ↗

<i>Gata2</i> -regulated <i>Gfi1b</i> expression controls endothelial programming during endothelial-to-hematopoietic transitionSemantic proximity Read ↗

Regulation of Hemogenic Endothelial Cell Development and FunctionSemantic proximity Read ↗

Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endotheliumSemantic proximity Read ↗

Hypoxia affects mesoderm and enhances hemangioblast specification during early development.Semantic proximity Read ↗

Induction of a hemogenic program in mouse fibroblasts.Semantic proximity Read ↗

Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endotheliumSemantic proximity Read ↗

LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.Semantic proximity Read ↗

Continuous single cell transcriptome dynamics reveal a default vascular smooth muscle fate of FLK1 mesodermSemantic proximity Read ↗

Zebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.