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Article

Regulation of Cardiovascular Development and Physiology by Hypoxia‐Inducible Factor 1<sup>a</sup>

1 Jun 1999

Abstract excerpt

Hypoxia is an essential pathophysiologic component of ischemic cardiovascular disease. A better understanding of the molecular mechanisms underlying adaptive responses to hypoxia may lead to novel therapeutic strategies. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic-helix-loop-helix-PAS domain transcription factor that mediates changes in gene expression in response to changes in O2 concentration....

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Identifiers

PMID: 10415537
DOI: 10.1111/j.1749-6632.1999.tb09241.x

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