Article
Biochemical and functional analyses of chromatin changes at the TCR-beta gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1998
Chattopadhyay S, Whitehurst C E, Schwenk F, Chen J
Abstract excerpt
Allelic exclusion is the process wherein lymphocytes express Ag receptors from only one of two possible alleles, and is effected through a feedback inhibition of further rearrangement of the second allele. The feedback signal is thought to cause chromatin changes that block accessibility of the s...
Topics
- Alleles
- Animals
- CD4 Antigens
- CD8 Antigens
- Cell Differentiation
- Chromatin
- DNA Methylation
- Deoxyribonuclease I
- Gene Deletion
- Genes, T-Cell Receptor beta
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NZB
- Mice, Knockout
- Mice, Transgenic
- Mutagenesis, Site-Directed
- Research Design
- T-Lymphocyte Subsets