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Article

Biochemical and functional analyses of chromatin changes at the TCR-beta gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1998

Chattopadhyay S, Whitehurst C E, Schwenk F, Chen J

Abstract excerpt

Allelic exclusion is the process wherein lymphocytes express Ag receptors from only one of two possible alleles, and is effected through a feedback inhibition of further rearrangement of the second allele. The feedback signal is thought to cause chromatin changes that block accessibility of the second allele to the recombinase. To identify the putative chromatin changes associated with allelic exclusion, we...

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PMID: 9570542

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Biochemical and functional analyses of chromatin changes at the TCR-beta gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation.PMID 9570542Read ↗

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