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Article

Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2010

Brady Brenna L, Oropallo Michael A, Yang-Iott Katherine S, Serwold Thomas, Hochedlinger Konrad, Jaenisch Rudolf, Weissman Irving L, Bassing Craig H

Abstract excerpt

The genomic organization of TCRbeta loci enables Vbeta-to-DJbeta2 rearrangements on alleles with assembled VbetaDJbetaCbeta1 genes, which could have deleterious physiologic consequences. To determine whether such Vbeta rearrangements occur and, if so, how they might be regulated, we analyzed mice with TCRbeta alleles containing preassembled functional VbetaDJbetaCbeta1 genes. Vbeta10 segments were transcribed,...

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Source

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Identifiers

PMID: 20709953
DOI: 10.4049/jimmunol.0903098
PMCID: PMC2933292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.PMID 20709953Read ↗

Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes.Semantic proximity Read ↗

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Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.Semantic proximity Read ↗

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Intra- and inter-allelic ordering of T cell receptor beta chain gene assembly.Semantic proximity Read ↗

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A change in the structure of Vbeta chromatin associated with TCR beta allelic exclusion.Semantic proximity Read ↗

Poor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion.Semantic proximity Read ↗

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