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Article

Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007

Wu Cherry, Ranganath Sheila, Gleason Megan, Woodman Barbara B, Borjeson Tiffany M, Alt Frederick W, Bassing Craig H

Abstract excerpt

T cell antigen receptor (TCR)beta V(D)J variable region exon assembly is ordered, with Dbeta to Jbeta rearrangements occurring before joining of Vbetas to a DJbeta complex. Germ-line V(D)J segments are flanked by recombination signal (RS) sequences, which consist of heptamers and nonamers separated by a spacer of 12 (12-RS) or 23 (23-RS) bp. V(D)J recombination is restricted by the 12/23 rule; joining occurs only...

Topics

Alleles
Animals
Base Sequence
Blastocyst
Cell Separation
Embryonic Stem Cells
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Heterozygote
Hybridomas
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Receptors, Antigen, T-Cell, alpha-beta

Recombination, Genetic

Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 17360467
DOI: 10.1073/pnas.0700081104
PMCID: PMC1820698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.PMID 17360467Read ↗

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