Article
Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.
Nature - 1 Jun 2000
Bassing C H, Alt F W, Hughes M M, D'Auteuil M, Wehrly T D, Woodman B B, Gärtner F, White J M, Davidson L, Sleckman B P
Abstract excerpt
The genes encoding the variable regions of lymphocyte antigen receptors are assembled from variable (V), diversity (D) and joining (J) gene segments. V(D)J recombination is initiated by the recombinase activating gene (RAG)-1 and -2 proteins, which introduce DNA double-strand breaks between the V, D and J segments and their flanking recombination signal sequences (RSSs). Generally expressed DNA repair proteins...
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