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Article

Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2010

Steinel Natalie C, Brady Brenna L, Carpenter Andrea C, Yang-Iott Katherine S, Bassing Craig H

Abstract excerpt

Feedback inhibition of V(D)J recombination enforces Ag receptor allelic exclusion in mammalian lymphocytes. Yet, in-frame VbetaDJbeta exons can assemble on both alleles in human and mouse alphabeta T lineage cells. To elucidate mechanisms that enforce TCRbeta allelic exclusion in such cells, we analyzed Vbeta expression and rearrangement in mice containing a functional Vbeta14DJbeta1.5Cbeta1 gene (Vbeta14(NT))...

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Source

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Identifiers

PMID: 20562258
DOI: 10.4049/jimmunol.0903099
PMCID: PMC2920457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes.PMID 20562258Read ↗

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