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Article

Disruption of the lineage restriction of TCR beta gene rearrangements.

European journal of immunology - 1 Nov 2002

Eyquem Stéphanie, Lagresle Chantal, Fasseu Magali, Sigaux François, Bories Jean-Christophe

Abstract excerpt

Despite a common lymphoid recombinase, assembly of Ig genes is restricted to B cells, whereas TCR loci rearrange in T cells. Transcriptional promoters and enhancers are critical for the regulation of the recombination process. However, the specific function of such elements in conferring the lineage-restriction of V(D)J recombination remains poorly understood. To gain further insights into the mechanism...

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Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Share to Genes, T-Cell Receptor beta

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Source

Identifiers

PMID: 12555671
DOI: 10.1002/1521-4141(200211)32:11<3256::AID-IMMU3256>3.0.CO;2-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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