Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

doi:10.1073/pnas.93.15.7871

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Article

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 1996

Bories J C, Demengeot J, Davidson L, Alt F W

Abstract excerpt

To assess the role of transcriptional enhancers in regulating accessibility of the T-cell receptor beta-chain (TCRbeta) locus, we generated embryonic stem cell lines in which a single allelic copy of the endogenous TCRbeta enhancer (Ebeta) was either deleted or replaced with the immunoglobulin he...

Topics

Alleles
Animals
B-Lymphocytes
Base Sequence
Blastocyst
Cells, Cultured
Chimera
DNA Nucleotidyltransferases
DNA Primers
DNA-Binding Proteins
Enhancer Elements, Genetic
Gene Deletion
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Complementation Test

Genomic Library

Immunoglobulin Heavy Chains

Immunoglobulin Joining Region

Immunoglobulin Variable Region

Source

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Identifiers

PMID: 8755569
DOI: 10.1073/pnas.93.15.7871
PMCID: PMC38841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8755569-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.