Article
Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver.
Pharmacogenetics - 1 Mar 2004
Lang Thomas, Hitzl Monika, Burk Oliver, Mornhinweg Esther, Keil Andrea, Kerb Reinhold, Klein Kathrin, Zanger Ulrich M, Eichelbaum Michel, Fromm Martin F
Abstract excerpt
AIMS: To determine the genetic variability of multidrug resistance protein 3 (MRP3). METHODS: Genomic DNA samples from 103 Caucasians were systematically screened for genetic variations to find a potential relationship with hepatic MRP3 expression. Sequencing comprised all 31 exons, approximately 100 bp of the flanking intronic regions and 2 kb of the 5' UTR. RESULTS: In total, 51 mutations were identified....
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