Article
Genetic variations of the ABC transporter gene ABCC3 in a Japanese population.
Drug metabolism and pharmacokinetics - 1 Apr 2007
Fukushima-Uesaka Hiromi, Saito Yoshiro, Maekawa Keiko, Hasegawa Ryuichi, Suzuki Kazuko, Yanagawa Tatsuo, Kajio Hiroshi, Kuzuya Nobuaki, Noda Mitsuhiko, Yasuda Kazuki, Tohkin Masahiro, Sawada Jun-ichi
Abstract excerpt
An ATP-binding cassette transporter, multidrug resistance-related protein 3 (MRP3), is encoded by the ABCC3 gene. The MRP3 protein is expressed in several tissues, and functions as an efflux transporter for conjugated as well as unconjugated substrates. In this study, the 31 ABCC3 exons and their flanking introns were comprehensively screened for genetic variations in 89 Japanese subjects. Forty-six genetic...
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