Article
Could polymorphisms in ATP-binding cassette C3/multidrug resistance associated protein 3 (ABCC3/MRP3) modify colorectal cancer risk?
European journal of cancer (Oxford, England : 1990) - 1 Apr 2008
Campa Daniele, Vodicka Pavel, Pardini Barbara, Novotny Jan, Försti Asta, Hemminki Kari, Barale Roberto, Canzian Federico
Abstract excerpt
Multidrug resistance associated protein 3 (ABCC3/MRP3) mediates the efflux of bile salts and several conjugated organic anions out of cells and could be involved in protecting tissues from xenobiotic accumulation and resulting toxicity. In this report, we investigated the hypothesis that a functional missense variant, namely the Arg1297His, and a polymorphism in the promoter region, namely the -211 C>T of the...
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