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Article

Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.

Pharmacogenetics and genomics - 1 Sept 2008

Kobayashi Kazuhiro, Ito Kousei, Takada Tappei, Sugiyama Yuichi, Suzuki Hiroshi

Abstract excerpt

OBJECTIVES: The multidrug resistance-associated protein 3/ATP-binding cassette transmembrane transporter subfamily C member 3 (MRP3/ABCC3) plays an important role in exporting endogenous and xenobiotic anionic substrates, including glucuronide conjugates of xenobiotics, from hepatocytes into the blood circulation. This excretory function of ABCC3 becomes very apparent particularly under cholestatic conditions,...

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Source

Identifiers

PMID: 18698235
DOI: 10.1097/FPC.0b013e328306e9ae

Genes

ABCC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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