Article
Genetic variations of the ABCC2 gene in the Chinese, Malay, and Indian populations of Singapore.
Drug metabolism and pharmacokinetics - 1 Jan 2008
Ho Woon Fei, Koo Seok Hwee, Yee Jie Yin, Lee Jon Deoon
Abstract excerpt
MRP2 is a drug transporter that is responsible for the gastrointestinal absorption and biliary excretion of a wide variety of endogenous and xenobiotic compounds, including many clinically used drugs. This study aims to identify genetic variations of ABCC2 gene in three distinct ethnic groups of the Singaporean population (n = 288). The coding region of the gene encoding the transporter protein was screened for...
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