Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of the polymorphism -211C>T in the regulatory region of the human ABCC3 gene.

Life sciences - 27 Mar 2007

Gradhand Ulrike, Tegude Heike, Burk Oliver, Eichelbaum Michel, Fromm Martin F, König Jörg

Abstract excerpt

The multidrug resistance protein 3 (MRP3/gene symbol: ABCC3) is an ATP-dependent efflux pump mediating the transport of endogenous glucuronides and conjugated drug metabolites across cell membranes. In humans the hepatic expression of ABCC3 mRNA seems to be influenced by the polymorphism C>T at the position -211 in the promoter of the ABCC3 gene. The aim of this study was to investigate the possible mechanisms of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Genes, Reporter

Share to Luciferases

Share to Multidrug Resistance-Associated Proteins

Share to Regulatory Sequences, Nucleic Acid

Share to Transfection

Source

Identifiers

PMID: 17300812
DOI: 10.1016/j.lfs.2007.01.023

Genes

ABCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Functional analysis of the polymorphism -211C>T in the regulatory region of the human ABCC3 gene.PMID 17300812Read ↗

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver.Semantic proximity Read ↗

Systematic screening of human ABCC3 polymorphisms and their effects on MRP3 expression and function.Semantic proximity Read ↗

Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3)Semantic proximity Read ↗

Could polymorphisms in ATP-binding cassette C3/multidrug resistance associated protein 3 (ABCC3/MRP3) modify colorectal cancer risk?Semantic proximity Read ↗

Genetic variations of the ABC transporter gene ABCC3 in a Japanese population.Semantic proximity Read ↗

Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element.Semantic proximity Read ↗

Aberrant regulation of the MRP3 gene in non-small cell lung carcinoma.Semantic proximity Read ↗

Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.