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Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

1 Mar 2001

Abstract excerpt

Proteins encoded by the human CYP3A genes metabolize every second drug currently in use. The activity of CYP3A gene products in the general population is highly variable and may affect the efficacy and safety of drugs metabolized by these enzymes. The mechanisms underlying this variability are poorly understood, but they include gene induction, protein inhibition and unknown genetic polymorphisms. To better...

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PMID: 11266076
DOI: 10.1097/00008571-200103000-00002

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